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<title>Abmart have SEAL and PETAL for protein research; Mabomics and MabArray for proteome research; SMAL for chemical immunology research.</title>
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<meta name="description" content="Abmart have developed SEAL and PETAL, for much faster, much more successful and even more cost-effective monoclonal antibody discovery than any previous approaches; Mabome and MabArray, for proteome-scale monoclonal antibody discovery and differential protein profiling; SMAL for affordable and productive monoclonal antibody discovery for small molecules.
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		<li><a href="<%=home%>" style="color: white">Home</a> > AbTech</li>
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							<td class="h1"><a name="abtechoverview"></a> AbTech Overview</td>
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							<td width="19%"><p>Abmart offers academic researchers, clinicians and product developers revolutionary technologies for fast, successful and cost-efficient discovery, detection and functional manipulation of proteins and chemical molecules.   Our long-term goal is to create an antibody democracy so that anyone with any molecule in mind can have desired monoclonal antibodies, successfully and affordably.</p>
								<p>
									Our technology starts with our technology team.  We have assembled a talented and passionate group of scientists in Shanghai to develop unique and powerful new antibody technologies.  This group (called <u><a href="<%=path%>/<%=abx %>_overview.html" target="_blank"> AbX&#8482;</a></u> within the company), consisting of biologists, physicists, computer scientists, chemists and technologists, is dedicated to solving important antibody problems with novel ideas and approaches. <a href="<%=path%>/<%=abx %>_overview.html" target="_blank"> AbX&#8482;</a> team members are ambitious, hard-working and practical.  Their work in the past
									few years have produced game-changing antibody products such as 30 day monoclonal antibodies (<a href="<%=path%>/<%=urgentmab %>_overview.html" target="_blank"> UrgentMab&#8482;</a> series based on <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a> technology) and functional monoclonal antibodies for challenging protein targets (ion channels) (<a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a> series based on <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a>).
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								<p>Our antibody technology &ldquo;ecosystem&rdquo; consists of the following components (Table 1)</p>
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										<th nowrap style="font-weight: bold" align=center>Technology<br>Application
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										<th style="font-weight: bold" align="center" width="30%">Description</th>
										<th style="font-weight: bold" align=center>Technology</th>
										<th style="font-weight: bold" align=center colspan=3>Technology-based Product Series</th>
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											<td rowspan="2">Protein Research</td>
											<td rowspan="2">for developing antibodies against single proteins</td>
											<td><a href="#sealtm" title="Surface Epitope Antibody Library">SEAL&#8482;</a></td>
											<td>SEAL&#8482;</td>
											<td>AbFocus&#8482;</td>
											<td>AbStop&#8482;</td>
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											<td><a href="#petaltm" title="Proteome Epitope Tag Antibody Library">PETAL&#8482;</a></td>
											<td>UrgentMab&#8482;</td>
											<td>AbX&#8482;</td>
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											<td rowspan=2>Proteome research</td>
											<td rowspan=2>Proteome-scale antibody development or differential profiling</td>
											<td><a href="#mabomicstm" title="Monoclonal Antibody Omics">Mabomics&#8482;</a></td>
											<td>Mabome&#8482;</td>
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											<td bgcolor="#ccc"><a href="#mabarraytm" title="Monoclonal Antibody Arrays">MabArray&#8482;</a></td>
											<td bgcolor="#ccc">AbTarget&#8482;</td>
											<td bgcolor="#ccc">AbProfiles&#8482;</td>
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											<td>Chemical immunology</td>
											<td>for developing antibodies against chemical moelcules</td>
											<td><a href="#smaltm" title="Small Molecule Antibody Library">SMAL&#8482;</a></td>
											<td>SMAL&#8482;</td>
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							<td><p>Together, these technologies enable much faster, more cost-effective, many times more successful and at a much larger scale for monoclonal antibody discovery, a fundamental activity with an ever increasing importance.</p></td>
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										<td class="h4 h2">AbClass&#8482;</td>
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													<td><img src="<%=path%>/res/img/abmart/arrow.png"></td>
													<td>Assigned as Easy, Hard and Crazy</td>
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													<td><img src="<%=path%>/res/img/abmart/arrow.png"></td>
													<td>Assignment is based on abundance, subcellular location, molecular function and protein superfamily</td>
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													<td><img src="<%=path%>/res/img/abmart/arrow.png"></td>
													<td>Such assignment is based on our past experience of generating antibodies for thousands of proteins</td>
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										<td class="h4 h2">AppClass&#8482;</td>
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													<td><img src="<%=path%>/res/img/abmart/arrow.png"></td>
													<td>WB is assigned as class I; IF, IHC are assigned as class II; IP/CHIP are class III; FCM and ELISA are class Dx and functional assays are class Tx.</td>
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							<td class="h1">AbTech platforms</td>
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							<td width="19%"><p class="h4 h2">
									<a name="proteinresearch"></a> Protein Research
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								<p>We have developed two revolutionary technologies, <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a>and <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a>, for much faster, much more successful and even more cost-effective monoclonal antibody discovery than any previous approaches.</p>
								<p>Traditional antibody approaches only probe a small fraction of surface sequences of a target protein due to high cost and research-like nature of antibody development. </p>
								
								<p>Our monoclonal antibody assembly line has achieved industrialized, high quality, high success rate and low cost antibody development. So we have developed two antibody technologies to take advantage of these features to offer an unparallel opportunity to explore protein surface sequences thoroughly with a large number of antibodies against all surface sequences, many times over.</p>
								
								<p>This shot-gun, library approach (<a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a>) has proven to be highly productive to identify functional sites of a protein for antibody targeting (Cell 157, 1393–404, 2014) .  To greatly cut down the time for monoclonal antibody development, we are launching <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a>-based product, <a href="<%=path%>/<%=abx %>_overview.html" target="_blank"> AbX&#8482;</a>, for developing monoclonal antibodies in about 30 days, roughly 20% of traditional method, while still delivering high affinity, specific antibodies.</p>
								
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										<a name="sealtm"></a> SEAL&#8482; for functional and detection antibody development for difficult targets  
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										<a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a>(<u>S</u>urface <u>E</u>pitope <u>A</u>ntibody <u>L</u>ibrary) is a library approach for deep coverage of a protein target with a large library of monoclonal antibodies against a large library of protein surface antigens.  <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a> consists of novel technologies for antigen design, potent immunogen preparation, efficient animal immunization, and large-scale antibody screening to produce high affinity, highly specific antibodies.  <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a> has proven to be a successful
										approach for developing antibodies for difficult applications (flow cytometry, IHC, IP and functional) against difficult targets such as membrane proteins (GPCRs, ion channels), transcription factors and signaling molecules.  Further, we have built an industrialized monoclonal antibody assembly line for making
									</p>
									<p><a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a> antibodies so that the unit cost for each antibody development is only at a small fraction of traditional approaches.  Together, <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a> offers an unprecedented freedom and success for monoclonal antibody discovery.</p>
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										<a name="petaltm"></a> PETAL&#8482;for ultra-fast, ultra low cost monoclonal antibody discovery
									</p>
									<p>To enable monoclonal antibody generation in weeks rather than months (from sequence), we have developed</p>
									
									<p>
										<a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a> (<u>P</u>roteome <u>E</u>pitope <u>T</u>ag <u>A</u>ntibody <u>L</u>ibrary), a proprietary, pre-made monoclonal antibody library with close to 50,000 mouse monoclonal antibodies against more than 20,000 peptide antigens representative of millions of proteins across hundreds of species.  For a target protein, multiple (typically 5-30) peptide antigens are designed and synthesized to screen the <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a> library (arrayed on chips).  Screening results of 5000 peptide
										antigens (derived from more than 400 proteins representative of more than 100 species) demonstrate that there 60 out of 100 peptide antigens can yield an average of 2 high affinity (dot blot detection sensitivity &lt;1 ng, comparable to a FLAG antibody) monoclonal antibodies.  So it is guaranteed to discover antibodies against a target if &gt;=4 peptide antigens are used for library screening.  Peptide synthesis and screening takes about 4-6 weeks.  <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a> offers a revolutionary
										way (we call this product AbX, for express, exploration or any target) for monoclonal antibody discovery for any protein target from any species.  Furthermore, we have priced AbX at a price similar to catalog antibodies so that everyone is able to afford to access <a href="<%=path%>/abtechnology.html#petaltm" target="_blank">PETAL&#8482;</a> for monoclonal antibody discovery.  
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							<td width="19%"><a name="proteomeresearch"></a>
								<p class="h4 h2">Proteome Research</p>
								<p>We have developed two revolutionary technologies, <a href="<%=path%>/<%=mabome %>_overview.html" target="_blank"> Mabome&#8482;</a>and <a href="<%=path%>/<%=mabome %>_overview.html" target="_blank">MabArray&#8482;</a>, for proteome-scale monoclonal antibody discovery and differential protein profiling .</p>
								<p>
									Despite the importance of <u>affinity proteomics </u>in basic and applied research,  it has not been widely adopted due to a lack of affinity reagents, particularly monoclonal antibodies.  The formidable cost and research-like nature of traditional antibody approaches make it impractical for proteome-scale antibody development.  
								</p>
								
								<p>Our monoclonal antibody assembly line has achieved industrialized, high quality, high success rate and low cost antibody development. So we have developed two proteome-scale antibody technologies to take advantage of these features to offer an unparallel opportunity to probe a proteome.</p>
								
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									<a name="mabomicstm"></a> Mabomics&#8482; for proteome-scale monoclonal antibody development 
								</p>
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									<a href="<%=path%>/<%=mabome %>_overview.html" target="_blank"> Mabome&#8482;</a> (<u>m</u>onoclonal <u>a</u>ntibody <u>omics</u>) develops monoclonal antibodies for thousands of expressed proteins in a proteome (biological sample).  A protein sample (for example, plasma; or a tissue; or a cellular organelle) is processed to produce protein and peptide fractions as immunogens.  A set of proprietary mouse monoclonal antibody technologies is employed to produce 10,000-100,000 individual mouse hybridomas to cover a significant portion (typically 30-70%) of
									the proteome.  Thus produced <a href="<%=path%>/<%=mabome %>_overview.html" target="_blank"> Mabome&#8482;</a> libraries have broad applications in differential proteomics and reagent development.
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									<a name="mabarraytm"></a> MabArray&#8482; antibody arrays for profiling thousands of cell surface and blood proteins
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								<p><a href="<%=path%>/<%=mabome %>_overview.html" target="_blank">MabArray&#8482;</a> is a massively parallel, proprietary antibody array platform with 10,000-30,000 pre-made monoclonal antibodies (using <a href="<%=path%>/<%=mabome %>_overview.html" target="_blank">Mabome&#8482;</a> technology) against diverse protein complexes including total cellular proteins, specific cellular organelle proteins (cell surface, and nuclear proteins) and plasma proteins.  MabArray&#8482; has proven to be able to measure thousands of cell surface and blood proteins.  MabArray&#8482; provides unbiased, high coverage profiling of
									expressed proteomes of cells, tissues and body fluids to enable high-throughput and efficient disease biomarkers and therapeutic targets discovery.</p>
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							<td width="19%"><a name="chemicalimmunology"></a>
								<p class="h4 h2">Chemical Immunology</p>
								<p>Despite its importance, monoclonal antibodies against small molecules including metabolites, drugs (antibiotics, chemotherapeutic drugs) and agricultural chemicals (pesticides) are difficult and expensive to develop. We have developed a proprietary process (SMAL&#8482;) for affordable and productive monoclonal antibody discovery for small molecules. </p>
							
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									<a name="smaltm"></a> SMAL&#8482; for high-success monoclonal antibody development against chemical molecules
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								<p>
									Similar to the library approach of <a href="<%=path%>/<%=seal %>_overview.html" target="_blank"> SEAL&#8482;</a>, <a href="<%=path%>/<%=smal %>_overview.html" target="_blank"> SMAL&#8482;</a> starts with a <u>c</u>ombinatorial <u>c</u>hemical <u>a</u>ntigen <u>l</u>ibrary (CCAL) design based on the specific structural features of a target chemical molecule.  CCAL typically consists of multiple chemical modifications of the target molecule so that different immunogenic and unique chemical groups are guaranteed to be exposed for generating antibodies. Thus produced CCAL is then going through the potent immunogen
									generation technology (VLP) developed at Abmart for high affinity and specific monoclonal antibody generation. <a href="<%=path%>/<%=smal %>_overview.html" target="_blank"> SMAL&#8482;</a> has proven to be effective for antibody development against diverse chemicals, thus providing key building blocks (antibodies) for building immunoassay-based detection of important small molecules.
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						<li><a href="#abtechoverview">AbTech Overview</a></li>
						<li><table width="100%" border="0">
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									<td>&nbsp;</td>
									<td colspan="2" nowrap><a href="#abclass">AbClass&#8482;</a></td>
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									<td>&nbsp;</td>
									<td colspan="2" nowrap><a href="#appclass">AppClass&#8482;</a></td>
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						<li><a href="#abtechplatforms">AbTech platforms</a></li>
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									<td>&nbsp;</td>
									<td colspan="2"><a href="#proteinresearch">Protein Research</a></td>
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									<td width="7%">&nbsp;</td>
									<td width="13%">&nbsp;</td>
									<td width="80%"><a href="#sealtm">SEAL&#8482;</a></td>
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									<td>&nbsp;</td>
									<td>&nbsp;</td>
									<td><a href="#petaltm">PETAL&#8482;</a></td>
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									<td>&nbsp;</td>
									<td colspan="2"><a href="#proteomeresearch">Proteome Research</a></td>
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									<td width="7%">&nbsp;</td>
									<td width="13%">&nbsp;</td>
									<td width="80%"><a href="#mabomicstm">Mabomics&#8482;</a></td>
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									<td>&nbsp;</td>
									<td>&nbsp;</td>
									<td><a href="#mabarraytm">MabArray&#8482;</a></td>
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									<td>&nbsp;</td>
									<td colspan="2" nowrap><a href="#chemicalimmunology">Chemical immunology</a></td>
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									<td width="7%">&nbsp;</td>
									<td width="13%">&nbsp;</td>
									<td width="80%"><a href="#smaltm">SMAL&#8482;</a></td>
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